Visible Light-Promoted Magnesium, Iron, and Nickel Catalysis Enabling C(sp3)–H Lactonization of 2-Alkylbenzoic Acids,Organic Letters

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Visible Light-Promoted Magnesium, Iron, and Nickel Catalysis Enabling C(sp3)–H Lactonization of 2-Alkylbenzoic Acids
Organic Letters ( IF 4.9 ) Pub Date : 2021-07-08 , DOI: 10.1021/acs.orglett.1c01984
Sasa Li ₁ , Mincong Su ₁ , Jie Sun ₁ , Kunjun Hu ₁ , Jian Jin ₁

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A mild and practical C(sp³)–H lactonization protocol has been achieved by merging photocatalysis and magnesium (iron, nickel) catalysis. A diverse range of 2-alkylbenzoic acids with a variety of substitution patterns could be transformed into the corresponding phthalide products. Based on the mechanistic experimentation and reported prior studies, a possible mechanism for the benzylic oxidative lactonization reaction was proposed with the hypothetic photoactive ternary complex formed between the 2-alkylbenzoic acid substrate, magnesium ion, and bromate anion.

中文翻译：

可见光促进的镁、铁和镍催化使 2-烷基苯甲酸的 C(sp3)-H 内酯化

通过合并光催化和镁（铁、镍）催化，实现了温和实用的 C(sp ³ )-H 内酯化方案。具有多种取代模式的多种 2-烷基苯甲酸可以转化为相应的邻苯二甲酸产品。基于机理实验和先前报道的研究，提出了苄基氧化内酯化反应的可能机制，假设光活性三元络合物在 2-烷基苯甲酸底物、镁离子和溴酸盐阴离子之间形成。

更新日期：2021-08-07

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