Abstract

Cyclohexane-1,3-dione derivatives are considered as a key structural precursor for the synthesis of plethora of synthetically significant compounds such as 4H-chromenones, 2H-xanthenones, coumarins, enaminones, acridinedione, 1,4-dihydropyridine, different other heterocycles, and natural products. These compounds show the diverse range of biological activities that include herbicidal, pesticidal, anti-bacterial, anti-inflammatory, anti-tumor, analgesic, anti-convulsant, anti-viral, anti-plasmodial, anti-malarial, anti-allergic, anti-cancer, etc. This versatility in the chemistry of cyclohexan-1,3-dione and its derivatives is due to the presence of highly active methylene moiety and its active di-carbonyl groups. There are only few reviews in the literature published on the synthetic application of cyclohexane-1,3-diones, but not on the synthesis of cyclohexane-1,3-dione and its derivatives. Keeping the importance of cyclohexane-1,3-dione derivatives in view, we inspired to do a compilation of their synthetic methods from different precursors, which are mainly published in last two decades.

摘要

环己烷-1,3-二酮衍生物被认为是合成大量具有重要合成意义的化合物的关键结构前体，例如 4 H-色酮、2 H-呫吨酮、香豆素、烯胺酮、吖啶二酮、1,4-二氢吡啶、不同的其他杂环和天然产物。这些化合物显示出多种生物活性，包括除草、杀虫、抗菌、抗炎、抗肿瘤、镇痛、抗惊厥、抗病毒、抗疟原虫、抗疟疾、抗过敏、抗- 癌症等。环己-1,3-二酮及其衍生物化学中的这种多功能性是由于高活性亚甲基部分及其活性二羰基的存在。关于环己烷-1,3-二酮的合成应用发表的文献评论很少，而对环己烷-1,3-二酮及其衍生物的合成则没有发表评论。考虑到环己烷-1,3-二酮衍生物的重要性，