Department of Physical Chemistry and Microreaction Technology Institute for Chemistry and Biotechnology Technical University of Ilmenau 98693 Ilmenau Germany
Department of Chemistry and Biochemistry The City College of The City University of New York New York NY 10031 USA
Polymer particles are soft and suitable for biological applications; fluorescent dyes are bright but quickly degrade. Thus, dye-doped fluorescent polymer particles are very promising for labeling. However, suitable tailoring of the particles is required, which can show biocompatibility, non-toxicity, and photostability. Therefore, in article number 2002219, Nikunjkumar R. Visaveliya and Johann Michael Köhler demonstrate various robust experimental strategies to bind fluorescent dyes in a polymer matrix covalently/non-covalently, as well as at the immediate surface via in-situ assembly and through bioconjugation. In this way, a multiscale and multicolor library of the fluorescent polymer particles for labeling applications, prepared by microfluidic supported syntheses, is established.
聚合物颗粒柔软，适合生物应用；荧光染料很亮但很快就会降解。因此，染料掺杂的荧光聚合物颗粒非常有希望用于标记。然而，需要对颗粒进行适当的定制，以表现出生物相容性、无毒和光稳定性。因此，在文章编号 2002219 中，Nikunjkumar R. Visaveliya 和 Johann Michael Köhler 展示了各种稳健的实验策略，以共价/非共价方式结合聚合物基质中的荧光染料，以及通过原位组装和生物偶联在直接表面结合。通过这种方式，建立了用于标记应用的荧光聚合物颗粒的多尺度和多色库，由微流体支持的合成制备。
京公网安备 11010802027423号