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Per-6-amino-beta-cyclodextrin as an efficient supramolecular ligand and host for Cu(I)-catalyzed N-arylation of imidazole with aryl bromides.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2008 Nov 21 , DOI: 10.1021/jo801811w
Palaniswamy Suresh 1 , Kasi Pitchumani 1
Affiliation  

Per-6-amino-beta-cyclodextrin (per-6-ABCD), acting simultaneously as a supramolecular ligand for CuI and host for aryl bromides, catalyzes N-arylation of imidazole with aryl bromides under mild conditions. This simple method proceeds with excellent yield for the coupling of imidazole with various substituted aryl bromides demonstrating good tolerance of other functionalities.

中文翻译:

Per-6-氨基-β-环糊精是一种有效的超分子配体,是Cu(I)催化的咪唑与芳基溴的N-芳基化反应的主体。

Per-6-氨基-β-环糊精(per-6-ABCD)同时充当CuI的超分子配体和芳基溴的主体,在温和条件下催化咪唑与芳基溴的N-芳基化。这种简单的方法以优异的收率进行了咪唑与各种取代的芳基溴化物的偶联反应,显示出对其他功能的良好耐受性。
更新日期:2017-01-31
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