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Liposome composition in drug delivery design, synthesis, characterization, and clinical application
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2021-07-02 , DOI: 10.1016/j.addr.2021.113851 Danielle E Large 1 , Rudolf G Abdelmessih 1 , Elizabeth A Fink 1 , Debra T Auguste 1
中文翻译：
药物递送设计、合成、表征和临床应用中的脂质体组合物
更新日期：2021-07-02
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2021-07-02 , DOI: 10.1016/j.addr.2021.113851 Danielle E Large 1 , Rudolf G Abdelmessih 1 , Elizabeth A Fink 1 , Debra T Auguste 1
Affiliation
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Liposomal drug delivery represents a highly adaptable therapeutic platform for treating a wide range of diseases. Natural and synthetic lipids, as well as surfactants, are commonly utilized in the synthesis of liposomal drug delivery vehicles. The molecular diversity in the liposome composition enables drug delivery with unique physiological functions, such as pH response, prolonged blood circulation, and reduced systemic toxicity. Herein, we discuss the impact of composition on liposome synthesis, function, and clinical utility.
中文翻译：
药物递送设计、合成、表征和临床应用中的脂质体组合物
脂质体药物递送代表了一种高度适应性的治疗平台，可用于治疗多种疾病。天然和合成脂质以及表面活性剂通常用于合成脂质体药物递送载体。脂质体组合物中的分子多样性使药物递送具有独特的生理功能，例如 pH 反应、延长血液循环和降低全身毒性。在此，我们讨论了成分对脂质体合成、功能和临床效用的影响。
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