Synthesis of 2-Pyrazolines from Hydrazines: Mechanisms Explained,ChemistrySelect

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Synthesis of 2-Pyrazolines from Hydrazines: Mechanisms Explained
ChemistrySelect ( IF 1.9 ) Pub Date : 2021-07-01 , DOI: 10.1002/slct.202101467
Teymour Vahedpour _{1,

2} , Maryam Hamzeh‐Mivehroud _{1,

2} , Salar Hemmati _{3,

4} , Siavoush Dastmalchi _{1,

2,

5}

Affiliation

2-Pyrazoline core is a very interesting five-membered heterocycle, which has been explored in recent years due to its vast applications as the core structure of bioactive and industrial agents. Based on literature studies, versatile synthetic approaches have been employed for the preparation of 2-pyrazolines, among them the reaction between hydrazines and α,β-unsaturated enones as the most used method. In this review article, different methods for the synthesis of 2-pyrazolines using hydrazine derivatives were classified and presented. Initially, numerous catalytic methods for the preparation of 2-pyrazolines from hydrazines and α,β-unsaturated enones are reviewed and various aspects of these methods discussed including catalyst efficiency, catalyst recovery, green chemistry, cost-effectiveness, scope of the method, enantioselectivity, and yield. In addition, reactions between hydrazines and other reagents in multicomponent and two-component reactions, developed recently, are discussed. Finally, some of the important applications of 2-pyrazolines are summarized.

中文翻译：

从肼合成 2-吡唑啉：机理解释

2-吡唑啉核是一种非常有趣的五元杂环，由于其作为生物活性剂和工业剂的核心结构的广泛应用，近年来得到了广泛的探索。根据文献研究，已采用多种合成方法来制备 2-吡唑啉，其中肼与 α,β-不饱和烯酮之间的反应是最常用的方法。在这篇综述文章中，对使用肼衍生物合成 2-吡唑啉的不同方法进行了分类和介绍。首先，回顾了许多用于从肼和 α,β-不饱和烯酮制备 2-吡唑啉的催化方法，并讨论了这些方法的各个方面，包括催化剂效率、催化剂回收率、绿色化学、成本效益、方法范围、对映选择性，和产量。此外，还讨论了最近开发的多组分和双组分反应中肼与其他试剂之间的反应。最后，总结了 2-吡唑啉的一些重要应用。

更新日期：2021-07-02

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