PVA/Poly(hexamethylene guanidine)/Gallic Acid Composite Hydrogel Films and Their Antibacterial Performance,ACS Applied Polymer Materials

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PVA/Poly(hexamethylene guanidine)/Gallic Acid Composite Hydrogel Films and Their Antibacterial Performance
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2021-07-01 , DOI: 10.1021/acsapm.1c00447
Xu Yang ₁ , Baolong Wang ₁ , Di Sha ₁ , Yonggang Liu ₁ , Zhi Liu ₁ , Kai Shi ₁ , Wei Liu ₁ , Cong Yu ₂ , Xiangling Ji ₁

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Carboxylated poly(vinyl alcohol) (PVA-COOH) is prepared by modifying PVA with succinic anhydride. Then, poly(hexamethylene guanidine (PHMG) as a cross-linker and gallic acid (GA) as an antioxidant are added to obtain PVA-based composite hydrogel films (PVA-COOH-PHMG/GA). The as-prepared PVA-based composite films show hydrophilic surfaces, high swelling ratios of 600–700%, low water solubility for PVA-COOH-PHMG samples (about 10%), and good mechanical properties. Importantly, when the initial bacterial concentration is 10⁷ CFU/mL, the antibacterial rate of PVA-based composite films against Escherichia coli and Staphylococcus aureus can reach 99.999%. When the initial bacterial concentration is 10⁸ CFU/mL, the antibacterial rates of these composite films against E. coli and S. aureus can be 99.9999% and 99.988%, respectively. The antibacterial mechanism is also discussed via a live/dead bacteria assay. The cytotoxicity test reveals that the resultant PVA-COOH-PHMG composite hydrogel films without GA have good biocompatibility toward L929 cells, but PVA-COOH-PHMG/GA composite films with addition of GA decrease the cell viability. Interestingly, the PVA-COOH-PHMG/GA composite hydrogel films can scavenge 70% of 1,1-diphenyl-2-picryhydrazyl (DPPH) free radical because of the release of GA, indicating an excellent antioxidant efficiency. It is anticipated that the resultant PVA-based composite hydrogel films with an adequate amount of GA not only possess excellent antibacterial properties but also exhibit a good antioxidant activity. Therefore, they show potential for biomedical field applications as wound dressings.

中文翻译：

PVA/聚（六亚甲基胍）/没食子酸复合水凝胶薄膜及其抗菌性能

羧化聚乙烯醇 (PVA-COOH) 是通过用琥珀酸酐改性 PVA 制备的。然后，加入作为交联剂的聚六亚甲基胍（PHMG）和作为抗氧化剂的没食子酸（GA），得到 PVA 基复合水凝胶薄膜（PVA-COOH-PHMG/GA）。复合膜显示出亲水性表面，600-700% 的高溶胀率，PVA-COOH-PHMG 样品的低水溶性（约 10%），以及良好的机械性能。重要的是，当初始细菌浓度为 10 ⁷ CFU/mL 时， PVA基复合薄膜对大肠杆菌和金黄色葡萄球菌的抑菌率可达99.999%，当初始细菌浓度为10 ⁸CFU/mL，这些复合膜对大肠杆菌和金黄色葡萄球菌的抗菌率可以分别为 99.9999% 和 99.988%。还通过活/死细菌测定讨论了抗菌机制。细胞毒性试验表明，所得不含 GA 的 PVA-COOH-PHMG 复合水凝胶膜对 L929 细胞具有良好的生物相容性，但添加 GA 的 PVA-COOH-PHMG/GA 复合膜降低了细胞活力。有趣的是，由于 GA 的释放，PVA-COOH-PHMG/GA 复合水凝胶膜可以清除 70% 的 1,1-二苯基-2-苦基肼 (DPPH) 自由基，表明具有优异的抗氧化效率。预计得到的含有足够量 GA 的 PVA 基复合水凝胶膜不仅具有优异的抗菌性能，而且还表现出良好的抗氧化活性。因此，它们显示出作为伤口敷料在生物医学领域应用的潜力。

更新日期：2021-08-13

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