姜黄素微球/ IR820混合双功能的水凝胶用于原位骨肉瘤化疗<i>共</i>-热疗法和骨重建,ACS Applied Materials & Interfaces

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姜黄素微球/ IR820混合双功能的水凝胶用于原位骨肉瘤化疗共-热疗法和骨重建
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-06-30 , DOI: 10.1021/acsami.1c08775
Bowen Tan ₁ , Yanting Wu ₁ , Yongzhi Wu ₁ , Kun Shi ₂ , Ruxia Han ₂ , Yiling Li ₁ , Zhiyong Qian ₂ , Jinfeng Liao ₁

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传统的生物材料介导的骨肉瘤治疗主要侧重于其抗肿瘤作用，但往往未能克服治疗后骨组织缺损修复的问题。同时，微创给药方法正成为正常组织保存的焦点。在此，设计了一种可注射的姜黄素-微球/IR820 共载混合甲基纤维素水凝胶（Cur-MP/IR820 凝胶）平台，用于骨肉瘤治疗和骨再生。在体外，K7M2wt 骨肉瘤细胞被热疗和姜黄素根除。后来，姜黄素的持续释放促进了碱性磷酸酶的表达和骨间充质干细胞的钙沉积。在体内，这种混合水凝胶可以通过注射到达肿瘤部位，并由于热敏感性而变成水凝胶。在 808 nm 激光照射下，在 5 分钟内产生局部热疗（~51°C）以消融肿瘤。同时，热加速姜黄素释放和热增加细胞膜通透性导致肿瘤细胞凋亡。光热中的肿瘤联合化疗组从治疗后第2天起成功抑制。之后，由于姜黄素的持续释放，促进了骨骼重建。Cur-MP/IR820 水凝胶的化学-共热功效和成骨能力为治疗骨肉瘤提供了一种有前景的方法，并为治疗骨肿瘤和修复骨组织提供了启发。

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Curcumin-Microsphere/IR820 Hybrid Bifunctional Hydrogels for In Situ Osteosarcoma Chemo-co-Thermal Therapy and Bone Reconstruction

Conventional biomaterial-mediated osteosarcoma therapy mainly focuses on its antitumor effect yet often fails to overcome the problem of post-treatment bone tissue defect repair. Simultaneously, minimally invasive drug delivery methods are becoming spotlights for normal tissue preservation. Herein, an injectable curcumin-microsphere/IR820 coloaded hybrid methylcellulose hydrogel (Cur-MP/IR820 gel) platform was designed for osteosarcoma therapy and bone regeneration. In vitro, the K7M2wt osteosarcoma cells were eradicated by hyperthermia and curcumin. Later, the sustained release of curcumin promoted alkaline phosphatase expression and calcium deposition of bone mesenchymal stem cells. In vivo, this hybrid hydrogel could reach tumor site via injection and turned into hydrogel due to heat sensitivity. Under the irradiation of an 808 nm laser, localized hyperthermia (∼51 °C) generated in 5 min to ablate the tumor. Meanwhile, the thermal-accelerated curcumin release and thermal-increased cell membrane permeability led to tumor cell apoptosis. Tumors in photothermal-co-chemotherapy group were successfully restrained from day 2 after treatment. After that, bone reconstruction was promoted because of sustained released curcumin. The chemo-co-thermal efficacy and osteogenic capacity of Cur-MP/IR820 hydrogel suggest a promising approach to the treatment of osteosarcoma and provide provoking inspiration for treating bone tumors and repairing bone tissue.

更新日期：2021-07-14

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