<br>脂质纳米颗粒─从脂质体到 mRNA 疫苗递送，研究多样性和进步的前景,ACS Nano

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脂质纳米颗粒─从脂质体到 mRNA 疫苗递送，研究多样性和进步的前景
ACS Nano ( IF 15.8 ) Pub Date : 2021-06-28 , DOI: 10.1021/acsnano.1c04996
Rumiana Tenchov ₁ , Robert Bird ₁ , Allison E Curtze ₁ , Qiongqiong Zhou ₁

Affiliation

脂质纳米颗粒 (LNP) 已在整个制药行业出现，成为提供各种治疗药物的有前景的载体。 LNP 作为 COVID-19 mRNA 疫苗的重要组成部分目前备受关注，在有效保护 mRNA 并将其运输至细胞方面发挥着关键作用。脂质体是 LNP 的早期版本，是一种多功能纳米药物输送平台。多种脂质体药物已获批准并应用于医疗实践。后续几代脂质纳米载体，例如固体脂质纳米粒子、纳米结构脂质载体和阳离子脂质-核酸复合物，表现出更复杂的结构和增强的物理稳定性。 LNP 能够封装治疗药物并将其递送至体内特定位置，并在所需时间释放其内容物，为治疗多种疾病提供了一个有价值的平台。在这里，我们根据对 CAS 内容库（最大的人工管理的已发表科学知识库）的分析，展示了 LNP 相关科学出版物的概况，包括专利和期刊文章。确定了上升趋势，例如纳米结构脂质载体和固体脂质纳米颗粒成为多种制剂的首选平台。讨论了 LNP 制剂作为药物递送平台的最新进展，例如抗肿瘤和核酸治疗以及疫苗递送系统。还评估了其他领域的挑战和增长机会，例如医学成像、化妆品、营养和农用化学品。本报告旨在为那些对 LNP 纳米技术、其应用及其开发的全球研究工作感兴趣的人提供有用的资源。

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Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of the COVID-19 mRNA vaccines, LNPs play a key role in effectively protecting and transporting mRNA to cells. Liposomes, an early version of LNPs, are a versatile nanomedicine delivery platform. A number of liposomal drugs have been approved and applied to medical practice. Subsequent generations of lipid nanocarriers, such as solid lipid nanoparticles, nanostructured lipid carriers, and cationic lipid–nucleic acid complexes, exhibit more complex architectures and enhanced physical stabilities. With their ability to encapsulate and deliver therapeutics to specific locations within the body and to release their contents at a desired time, LNPs provide a valuable platform for treatment of a variety of diseases. Here, we present a landscape of LNP-related scientific publications, including patents and journal articles, based on analysis of the CAS Content Collection, the largest human-curated collection of published scientific knowledge. Rising trends are identified, such as nanostructured lipid carriers and solid lipid nanoparticles becoming the preferred platforms for numerous formulations. Recent advancements in LNP formulations as drug delivery platforms, such as antitumor and nucleic acid therapeutics and vaccine delivery systems, are discussed. Challenges and growth opportunities are also evaluated in other areas, such as medical imaging, cosmetics, nutrition, and agrochemicals. This report is intended to serve as a useful resource for those interested in LNP nanotechnologies, their applications, and the global research effort for their development.

更新日期：2021-06-28

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