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Synthesis, crystal and biological activity of 5‑chloro-3-(2,4-dichlorophenyl)- N-(3-methoxyphenyl)-2-methyl-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine
Journal of Chemical Research ( IF 1.0 ) Pub Date : 2015-04-01 , DOI: 10.3184/174751915x14240937288831
Lu Jiu-fu 1 , Ge Hong-guang 1 , Zhang Hui 1 , Guo Jing-jing 1 , Liang Shan-shan 1 , Shi Juan 1
Affiliation  

The crystal structure of 5-chloro-3-(2,4-dichlorophenyl)-N-(3-methoxyphenyl)-2-methyl-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine (C26H19Cl3N4O, Mr = 509.80) has been synthesised by chlorination and aminisation from 3-(2,4-dichlorophenyl)-2-methyl-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diol. Its structure was confirmed by element analysis, IR, 1H NMR and X-ray diffraction. The crystal belongs to the triclinic system, space group P-1 with a = 10.979(2) Å, b= 11.339(2) Å, c= 11.646(2) Å, a= 98.58(3) °, β= 110.21(3) °, γ= 111.61 (3) °. In addition, the compound possesses moderate anticancer activity.

中文翻译:

5-氯-3-(2,4-二氯苯基)-N-(3-甲氧基苯基)-2-甲基-6-苯基吡唑并[1,5-a]嘧啶-7-胺的合成、晶体及生物活性

5-氯-3-(2,4-二氯苯基)-N-(3-甲氧基苯基)-2-甲基-6-苯基吡唑并[1,5-a]嘧啶-7-胺(C26H19Cl3N4O, Mr = 509.80) 是由 3-(2,4-二氯苯基)-2-甲基-6-苯基吡唑并[1,5-a]嘧啶-5,7-二醇通过氯化和胺化合成的。其结构经元素分析、IR、1H NMR和X射线衍射证实。该晶体属于三斜晶系,空间群 P-1,a = 10.979(2) Å, b= 11.339(2) Å, c= 11.646(2) Å, a= 98.58(3) °, β= 110.21( 3)°,γ=111.61 (3)°。此外,该化合物具有中等抗癌活性。
更新日期:2015-04-01
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