The title compound, 5-(4-fluorophenyl)-N,N-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, has been synthesised by condensation of dimethylamine with 5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid. This intermediate was prepared from ethyl 5-amino-1H-pyrazole-4-carboxylate by cyclisation with 4,4,4-trifluoro-1-(4-fluorophenyl)butane-1,3-dione and then saponification with sodium hydroxide. The crystal structure of the title compound was determined. The compound possesses distinct effective inhibition on the proliferation of some cancer cell lines.

中文翻译：

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5-(4-氟苯基) -N , N-二甲基-7-(三氟甲基)吡唑并[1,5 - a ]嘧啶-3-甲酰胺的合成、晶体结构和生物活性

标题化合物 5-(4-氟苯基)-N,N-二甲基-7-(三氟甲基)吡唑并[1,5-a]嘧啶-3-甲酰胺，通过二甲胺与5-(4-氟苯基)-7-(三氟甲基)吡唑并[1,5-a]嘧啶-3-羧酸。该中间体由5-氨基-1H-吡唑-4-羧酸乙酯通过与4,4,4-三氟-1-(4-氟苯基)丁烷-1,3-二酮环化，然后与氢氧化钠皂化而制备。确定了标题化合物的晶体结构。该化合物对某些癌细胞系的增殖具有明显的有效抑制作用。