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Synthesis of spiro indazole-tetrahydrothiophenes via sulfa-Michael/aldol cascade reactions
Journal of Chemical Research ( IF 1.0 ) Pub Date : 2017-11-01 , DOI: 10.3184/174751917x15094552081170
Shaowei Zhang 1 , Demin Ren 1 , Xiaolian Hu 1 , Xingliang Fu 1 , Xiaofang Li 1
Affiliation  

The sulfa-Michael/aldol cascade reaction of 5-arylmethylidene-1-phenyl-6,7-dihydro-1H-indazol-4(5H)-ones and 1,4-dithiane-2,5-diol yielded novel 2′-(4-aryl)-4′-hydroxy-1-phenyl-4′,5′,6,7-tetrahydro-2′H-spiro[indazole-5,3′-thiophen]-4(1H)-ones in moderate yields. The structures of all the products were characterised thoroughly by NMR, IR and HRMS, together with X-ray crystallographic analysis.

中文翻译:

通过磺胺-迈克尔/醛醇级联反应合成螺吲唑-四氢噻吩

5-芳基亚甲基-1-苯基-6,7-二氢-1H-吲唑-4(5H)-酮和1,4-二噻烷-2,5-二醇的磺胺-迈克尔/醛醇级联反应产生了新的2'- (4-芳基)-4'-羟基-1-苯基-4',5',6,7-四氢-2'H-螺[吲唑-5,3'-噻吩]-4(1H)-ones产量适中。所有产物的结构都通过NMR、IR和HRMS以及X射线晶体学分析进行了彻底表征。
更新日期:2017-11-01
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