Twelve new Schiff bases containing a disubstituted 1,2,4-triazole and a monosubstituted indole linked by a thioethyl group were efficiently synthesised via a method employing microwave irradiation. Compared with a conventional method of heating at 100 °C, yields were increased from 46–48 to 82–92% and the reaction times were reduced from 20–25 h to 4–7 min. The structures of these novel hexacyclic Schiff bases were characterised by their spectral data and elemental analysis. Evaluation of their antibacterial activity showed that many of them possess excellent activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus subtilis.

中文翻译：

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甲基1-{2-[4-amino-5-(naphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio]ethyl}-1H-indole-的微波辅助合成及抗菌活性3-羧酸衍生物

通过采用微波辐射的方法有效地合成了十二个含有双取代 1,2,4-三唑和单取代吲哚的新型席夫碱。与在 100°C 加热的传统方法相比，产率从 46-48% 增加到 82-92%，反应时间从 20-25 小时减少到 4-7 分钟。这些新型六环席夫碱的结构通过它们的光谱数据和元素分析来表征。对其抗菌活性的评价表明，它们中的许多对大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌和枯草芽孢杆菌具有优异的活性。