An efficient two-step route was developed for the synthesis of 1-aralkyl-4-benzylpiperazine derivatives by a Blanc reaction and alkylation. The key intermediate, N-benzylpiperazine, was prepared in an excellent yield by direct benzylation of commercially available piperazine under metal-free conditions.

中文翻译：

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1-芳烷基-4-苄基哌嗪衍生物的简便合成

开发了一种有效的两步路线，用于通过布兰克反应和烷基化合成 1-芳烷基-4-苄基哌嗪衍生物。关键中间体 N-苄基哌嗪是通过在无金属条件下直接对市售哌嗪进行苄基化制备的，产率很高。