A convenient and concise synthesis of 2-Fluoro-4-nitrobenzoic acid was obtained by oxidation of 2-fluoro-4-nitrotoluene with potassium permanganate in the presence of a phase transfer catalyst in 74% yield. N-methyl-2-fluoro-4-nitrobenzamide was then produced via chlorination and amination in 95% yield. Hydrogenation in the presence of Pd/C can afforded 4-amino-2-fluoro-N-methyl-benzamide in 98% yield

中文翻译：

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4-氨基-2-氟-N-甲基-苯甲酰胺的便捷合成

通过在相转移催化剂存在下用高锰酸钾氧化 2-氟-4-硝基甲苯，以 74% 的产率获得了 2-氟-4-硝基苯甲酸的简便而简洁的合成方法。然后通过氯化和胺化以 95% 的产率生产 N-甲基-2-氟-4-硝基苯甲酰胺。在 Pd/C 存在下氢化可以以 98% 的产率提供 4-amino-2-fluoro-N-methyl-benzamide