Construction of Axially Chiral Arylborons via Atroposelective Miyaura Borylation,Journal of the American Chemical Society

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Construction of Axially Chiral Arylborons via Atroposelective Miyaura Borylation
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2021-06-28 , DOI: 10.1021/jacs.1c04345
Kai Yang ₁ , Yanfei Mao ₁ , Jie Xu ₁ , Hao Wang ₁ , Yong He ₁ , Wangyang Li ₁ , Qiuling Song _{1,

2}

Affiliation

Compared with the well-developed centrally chiral boron chemistry, C–B axially chiral chemistry remains elusive and challenging. Herein we report the first atroposelective Miyaura borylation of bromoarenes with unsymmetrical diboron reagents for the direct catalytic synthesis of optically active atropisomeric arylborons. This reaction features broad substrate scope and produces axially chiral arylborons with high yields and good enantioselectivities.

中文翻译：

通过 Atroposelective Miyaura Borylation 构建轴向手性芳基硼

与发达的中心手性硼化学相比，C-B 轴向手性化学仍然难以捉摸和具有挑战性。在此，我们报告了第一次使用不对称二硼试剂对溴芳烃进行阻转选择性 Miyaura 硼酸化，用于直接催化合成旋光阻转异构芳基硼。该反应具有广泛的底物范围，可产生高产率和良好对映选择性的轴向手性芳基硼。

更新日期：2021-07-14

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