Chemically Triggered Hydrogel Transformations through Covalent Adaptable Networks and Applications in Cell Culture,ACS Macro Letters

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Chemically Triggered Hydrogel Transformations through Covalent Adaptable Networks and Applications in Cell Culture
ACS Macro Letters ( IF 5.1 ) Pub Date : 2021-06-28 , DOI: 10.1021/acsmacrolett.1c00276
Le Chang _{1,

2} , Cong Wang _{1,

2} , Shuang Han ₃ , Xiaolong Sun ₁ , Feng Xu _{1,

2}

Affiliation

In this article, we report a “smart” hydrogel system, which can be remodeled into multiple architectures through dynamic covalent adaptable networks. The topological changes in hydrogel structures yield dynamically tunable properties through the reformation of covalent chemical linkages via amine–thiol scrambling, thiol–thiol exchange, decoupling reaction, and disulfide formation. The stiffness of the hydrogels can be regulated via dynamic covalent bonding, with some hydrogels displaying self-healing and shear thinning properties, as demonstrated by rheological measurements. Significantly, the dramatic structural transformations are achieved under neutral aqueous conditions at room temperature. These “smart” hydrogels show good biocompatibility, which can induce cell growth in two-dimensional cell culture and effectively serve as a scaffold for encapsulating and releasing human mesenchymal stem cells in three-dimensional cell culture. Thus, the developed “smart” hydrogel system holds great potential in biomedical applications such as tissue engineering and cell therapy.

中文翻译：

通过共价适应性网络的化学触发水凝胶转化及其在细胞培养中的应用

在本文中，我们报告了一种“智能”水凝胶系统，可以通过动态共价自适应网络将其改造成多种架构。水凝胶结构的拓扑变化通过胺-硫醇加扰、硫醇-硫醇交换、去偶反应和二硫化物形成等方式重新形成共价化学键，从而产生动态可调的特性。水凝胶的刚度可以通过动态共价键来调节，如流变测量所示，一些水凝胶显示出自愈和剪切稀化特性。值得注意的是，在室温下中性水性条件下实现了显着的结构转变。这些“智能”水凝胶表现出良好的生物相容性，它可以在二维细胞培养中诱导细胞生长，并在三维细胞培养中有效地作为包裹和释放人间充质干细胞的支架。因此，开发的“智能”水凝胶系统在组织工程和细胞治疗等生物医学应用中具有巨大潜力。

更新日期：2021-07-20

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