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Efficient Preparation of Methyl 2-Oxo-3-aryl (heteroaryl)-2H-pyran-5-carboxylate via Pd-Catalyzed Negishi Coupling
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-06-28 , DOI: 10.1002/ejoc.202100608
Tania Xavier 1 , Christophe Pichon 2 , Marc Presset 1 , Erwan Le Gall 1 , Sylvie Condon 3
Affiliation  

A Negishi type coupling is reported allowing access to methyl 3-aryl (heteroaryl) coumalates. The synthesis of methyl coumalate adducts is characterized by a low catalyst loading, high functional tolerance, and high yields.
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中文翻译:

通过 Pd 催化的 Negishi 偶联有效制备 2-Oxo-3-芳基(杂芳基)-2H-吡喃-5-羧酸甲酯

据报道,Negishi 型偶联允许获得甲基 3-芳基(杂芳基)香豆酸酯。香豆酸甲酯加合物的合成具有催化剂负载量低、功能耐受性高和产率高的特点。
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更新日期:2021-07-08
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