具有集成液滴尺寸调节功能的微流控器件高分辨率 3D 打印柔性材料,ACS Applied Materials & Interfaces

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具有集成液滴尺寸调节功能的微流控器件高分辨率 3D 打印柔性材料
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-06-26 , DOI: 10.1021/acsami.1c05547
Niclas Weigel ₁ , Max J Männel ₁ , Julian Thiele ₁

Affiliation

我们通过由单体 2-苯氧基丙烯酸酯、交联剂 Ebecryl 8413、三（丙二醇）二丙烯酸酯或 1,3,5-trilyl-1 制成的投影微立体光刻 (PμSL) 筛选配方开发用于柔性微材料的高分辨率增材制造的树脂,3,5-triazine-2,4,6(1 H ,3 H ,5 H)-三酮、光吸收剂苏丹 1 和光引发剂二苯基(2,4,6-三甲基苯甲酰基)氧化膦。由该树脂库制成的 PμSL 印刷聚合物微材料的特征在于可实现的层厚度取决于紫外线照射能量，以及机械和光学特性。这种筛选方法中的最佳候选树脂允许 3D 打印最小横截面约为 35 × 46 μm ^{2 的}透明微通道，其对水、异丙醇、乙醇、n具有适当的耐溶剂性-己烷和 HFE-7500。机械性能注定用于具有需要高材料灵活性的集成功能单元的 3D 打印微流体设备。例如，我们设计了灵活的微通道，用于在微乳液形成中按需调节微滴尺寸。我们的两个集成液滴调节器的轮廓通过注入限定体积的空气进行操作，空气使形成液滴的微通道交叉连接变形，并改变其中的液滴尺寸。通过这项研究，我们将用于 PμSL 打印的功能树脂库扩展到具有微米分辨率的柔性材料，并为进一步探索这些材料提供基础，例如，作为具有明确力学的微结构细胞培养基材。

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Flexible Materials for High-Resolution 3D Printing of Microfluidic Devices with Integrated Droplet Size Regulation

We develop resins for high-resolution additive manufacturing of flexible micromaterials via projection microstereolithography (PμSL) screening formulations made from monomer 2-phenoxyethyl acrylate, the cross-linkers Ebecryl 8413, tri(propyleneglycol) diacrylate or 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione, the photoabsorber Sudan 1, and the photoinitiator diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide. PμSL-printed polymer micromaterials made from this resin library are characterized regarding achievable layer thickness depending on UV exposure energy, and for mechanical as well as optical properties. The best-candidate resin from this screening approach allows for 3D-printing transparent microchannels with a minimum cross section of approximately 35 × 46 μm², which exhibit proper solvent resistance against water, isopropanol, ethanol, n-hexane, and HFE-7500. The mechanical properties are predestined for 3D-printing microfluidic devices with integrated functional units that require high material flexibility. Exemplarily, we design flexible microchannels for on-demand regulation of microdroplet sizes in microemulsion formation. Our two outlines of integrated droplet regulators operate by injecting defined volumes of air, which deform the droplet-forming microchannel cross-junction, and change the droplet size therein. With this study, we expand the library of functional resins for PμSL printing toward flexible materials with micrometer resolution and provide the basis for further exploration of these materials, e.g., as microstructured cell-culturing substrates with defined mechanics.

更新日期：2021-07-07

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