Tissue Fluid Triggered Enzyme Polymerization for Ultrafast Gelation and Cartilage Repair,Angewandte Chemie International Edition

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Tissue Fluid Triggered Enzyme Polymerization for Ultrafast Gelation and Cartilage Repair
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-06-25 , DOI: 10.1002/anie.202107789
Qi Zhang _{1,

2} , Huaxing Xu ₃ , Chu Wu ₁ , Yinghui Shang ₁ , Qing Wu ₁ , Qingcong Wei ₁ , Qi Zhang ₄ , Yao Sun ₄ , Qigang Wang ₁

Affiliation

The in situ gelation of injectable precursors is desirable in the field of tissue regeneration, especially in the context of irregular defect filling. The current driving forces for fast gelation include the phase-transition of thermally sensitive copolymers, click chemical reactions with tissue components, and metal coordination effect. However, the rapid formation of tough hydrogels remains a challenge. Inspired by aerobic metabolism, we herein propose a tissue-fluid-triggered cascade enzymatic polymerization process catalyzed by glucose oxidase and ferrous glycinate for the ultrafast gelation of acryloylated chondroitin sulfates and acrylamides. The highly efficient production of carbon radicals and macromolecules contribute to rapid polymerization for soft tissue augmentation in bone defects. The copolymer hydrogel demonstrated the regeneration-promoting capacity of cartilage. As the first example of using artificial enzyme complexes for in situ polymerization, this work offers a biomimetic approach to the design of strength-adjustable hydrogels for bio-implanting and bio-printing applications.

中文翻译：

用于超快速凝胶和软骨修复的组织液触发酶聚合

可注射前体的原位凝胶化在组织再生领域是可取的，特别是在不规则缺陷填充的情况下。当前快速凝胶化的驱动力包括热敏共聚物的相变、与组织成分的点击化学反应和金属配位效应。然而，快速形成坚韧的水凝胶仍然是一个挑战。受有氧代谢的启发，我们在此提出了一种由葡萄糖氧化酶和甘氨酸亚铁催化的组织液触发的级联酶聚合过程，用于丙烯酰化硫酸软骨素和丙烯酰胺的超快速凝胶化。碳自由基和大分子的高效生产有助于骨缺损中软组织增强的快速聚合。共聚物水凝胶证明了软骨的再生促进能力。作为使用人工酶复合物进行原位聚合的第一个例子，这项工作为设计用于生物植入和生物打印应用的强度可调水凝胶提供了一种仿生方法。

更新日期：2021-08-26

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