自供电可控透皮给药系统,Advanced Functional Materials

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自供电可控透皮给药系统
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-06-25 , DOI: 10.1002/adfm.202104092
Yuan Yang _{1,

2} , Lingling Xu _{1,

2} , Dongjie Jiang _{1,

2} , Bo Zhi Chen ₃ , Ruizeng Luo _{1,

4} , Zhuo Liu ₅ , Xuecheng Qu _{1,

2} , Chan Wang _{1,

2} , Yizhu Shan _{1,

2} , Yong Cui ₆ , Hui Zheng ₇ , Zhiwei Wang _{1,

2} , Zhong Lin Wang _{1,

2,

8} , Xin Dong Guo ₃ , Zhou Li _{1,

2,

4}

Affiliation

CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro‐nano Energy and Sensor Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 China
School of Nanoscience and Technology University of Chinese Academy of Sciences Beijing 100049 China
Beijing Laboratory of Biomedical Materials College of Materials Science and Engineering Beijing University of Chemical Technology Beijing 100029 China
Center of Nanoenergy Research School of Physical Science and Technology Guangxi University Nanning 530004 China
Beijing Advanced Innovation Centre for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beihang University Beijing 100191 China
Department of Dermatology China‐Japan Friendship Hospital Beijing 100029 China
Department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China
School of Materials Science and Engineering Georgia Institute of Technology Atlanta GA 30332 0245 USA

传统的外用软膏涂在皮肤表面，由于牛皮癣角质层增厚，药物渗透性差。微针 (MN) 为促进药物渗透提供了理想的机会。然而，普通的MNs难以满足按需给药的要求。在这项研究中，通过引入聚吡咯 (PPy) 导电材料制造了一种智能电响应 MN。此外，还开发了一种基于压电纳米发电机（PENG）的自供电可控透皮给药系统（sc-TDDS）。sc-TDDS 可以通过收集机械能并将其转换为电能来控制药物释放。sc-TDDS 每次电刺激可皮下释放 8.5 ng 地塞米松 (Dex)。使用 sc-TDDS 治疗银屑病样皮肤病时，5天后炎性皮肤恢复正常，明显优于传统的Dex溶液涂层处理。这项工作为各种疾病治疗方案提供了一种有前途的按需透皮药物释放方法。

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更新日期：2021-09-03

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