Oxindole has been shown to be a pharmacologically advantageous scaffold having many biological properties that are relevant to medicinal chemistry. The simplicity and widespread occurrence of this scaffold in plant-based alkaloids have further reinforced oxindole’s merit in the domain of novel drug discovery. First extracted from Uncaria tomentosa, commonly the known as cat claw’s plant which was found abundantly in the Amazon rainforest, molecules with the oxindole moiety have been shown to be common in a wide variety of compounds extracted from plant sources. The role of oxindole as a chemical scaffold for fabricating and designing biological drugs agents can be ascribed to its ability to be modified by a number of chemical groups to generate novel biological functions. This review is aimed at providing a description of the general chemistry based on existing corresponding structure-activity relationships (SARs) and compile

中文翻译：

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羟吲哚及其衍生物：生物活性最新进展综述


羟吲哚已被证明是一种药理学上有利的支架，具有许多与药物化学相关的生物学特性。这种支架在植物生物碱中的简单性和广泛存在进一步增强了羟吲哚在新药发现领域的优点。具有羟吲哚部分的分子首先从毛钩藤（通常被称为猫爪草，在亚马逊雨林中大量发现）中提取，已被证明在从植物源中提取的多种化合物中很常见。羟吲哚作为制造和设计生物药物制剂的化学支架的作用可以归因于它能够被许多化学基团修饰以产生新的生物功能。本综述旨在根据现有相应的构效关系（SAR）提供一般化学的描述，并编译