<br>苗酸汤通过AMPK信号通路对高脂饮食肥胖大鼠高脂血症的影响,Food Science & Nutrition

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苗酸汤通过AMPK信号通路对高脂饮食肥胖大鼠高脂血症的影响
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2021-06-23 , DOI: 10.1002/fsn3.2394
Hongmei Yang ₁ , Jiao Xie ₁ , Nanlan Wang ₁ , Qianqian Zhou ₁ , Yang Lu _{1,

2} , Zihan Qu _{1,

3} , Huiqun Wang ₁

Affiliation

高脂血症是肥胖动物的共同特征。确定参与调节膳食脂质代谢的因素是改善健康最有益的方法。苗酸汤（MSS）是一种由番茄和红辣椒制成的发酵食品，含有番茄红素、辣椒素和有机酸。我们进行这项研究的目的是探讨MSS对高脂饮食诱导的肥胖大鼠血脂水平的调节功能和机制。在我们的预防性研究中，大鼠喂食正常饮食（ND1）、高脂饮食（HFD1）、HFD + 4 g/kg BW MSS（HFD + LS1）和HFD + 8 g/kg BW MSS（HFD + HS1）。我们发现MSS显着降低了大鼠的体重和脂肪积累并改善了血脂水平。 MSS 显着增加 AMP 激活蛋白激酶-α (AMPKα) 的表达，减弱脂肪形成转录因子甾醇调节元件结合蛋白-1c (SREBP-1c) 的表达，并抑制脂肪酸合酶 (FAS) 的表达和乙酰辅酶A羧化酶α（ACCα），肝脏脂质代谢的关键调节因子。此外，我们还进行了一项治疗研究，将大鼠分组接受 ND2、HFD2、PC2、HFD + LS2 和 HFD + HS2 再持续 10 周。 MSS 治疗可降低体重、脂肪沉积和脂滴百分比，并调节血浆脂质含量。 MSS显着增加AMPK的表达并减轻SREBP-1c、ACC和FAS的表达。综上所述，这些发现表明 MSS 通过调节 AMPK 信号通路来预防和治疗肥胖大鼠的高脂血症。

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Effects of Miao sour soup on hyperlipidemia in high-fat diet-induced obese rats via the AMPK signaling pathway

Hyperlipidemia is a common characteristic of obese animals. Identifying the factors involved in the regulation of dietary lipid metabolism is the most beneficial way to improve health. Miao sour soup (MSS) is a fermented food made from tomato and red pepper that contains lycopene, capsaicin, and organic acids. We conducted this study to investigate the regulatory functions and mechanisms of MSS on the blood lipid levels of high-fat diet-induced obese rats. In our preventive study, rats were fed normal diet (ND1), high-fat diet (HFD1), HFD + 4 g/kg BW MSS (HFD + LS1), and HFD + 8 g/kg BW MSS (HFD + HS1). We found that MSS significantly reduced the body weight and fat accumulation and improved the blood lipid levels of rats. MSS significantly increased the expression of AMP-activated protein kinase-alpha (AMPKα), attenuated the expression of the adipogenic transcription factor sterol regulatory element-binding protein-1c (SREBP-1c), and suppressed the expression of fatty acid synthase (FAS) and acetyl-CoA carboxylase alpha (ACCα), the critical regulators of hepatic lipid metabolism. Additionally, we also conducted a treatment study, and we grouped rats to receive ND2, HFD2, PC2, HFD + LS2, and HFD + HS2 for another 10 weeks. MSS treatment reduced the body weight, fat deposition, and percentage of lipid droplets and regulated the plasma lipid content. MSS significantly increased the expression of AMPK and alleviated the expression of SREBP-1c, ACC, and FAS. Taken together, these findings suggest that MSS prevents and treats hyperlipidemia in obese rats by regulating the AMPK signaling pathway.

更新日期：2021-08-12

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