一种具有聚集诱导发射的可激活探针，用于通过光声成像和 NIR-II 荧光成像检测和成像草药引起的肝损伤,Advanced Healthcare Materials

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一种具有聚集诱导发射的可激活探针，用于通过光声成像和 NIR-II 荧光成像检测和成像草药引起的肝损伤
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-06-23 , DOI: 10.1002/adhm.202100867
Lihe Sun ₁ , Juan Ouyang ₁ , Yunqing Ma ₁ , Zhuo Zeng ₁ , Cheng Zeng ₁ , Fang Zeng ₁ , Shuizhu Wu ₁

Affiliation

虽然草药广泛用于促进健康和治疗慢性病，但使用不当可能会导致肝损伤等不良反应，准确评估其肝毒性对公众健康具有重要意义。本文展示了一种可激活探针 QY-N，用于通过 NIR-II 荧光和多光谱光声断层扫描 (MSOT) 成像检测肝脏 NO 来诊断草药引起的肝损伤。该探针包括作为电子供体的含双甲氧基苯基胺的二羟基蒽，作为电子受体的喹啉鎓，以及作为识别基团和荧光猝灭剂的丁胺。肝脏水平的 NO 与丁胺反应，从而产生活化的探针 QY-NO，它表现出用于光声成像的红移吸收带（700-850 nm）并产生用于 NIR-II 荧光成像的强发射（910-1110 nm）。QY-NO 具有聚集诱导发射 (AIE) 活性，可确保在聚集状态下具有强发射。将QY-N用于雷公藤内酯源性肝损伤小鼠模型，实验结果表明QY-N可被肝脏NO激活，因此可用于检测中草药性肝损伤。三维 MSOT 图像提供的时空信息很好地描绘了肝损伤的部位和大小。此外，QY-N 还被用于监测治疗过程中肝损伤的康复情况。QY-NO 具有聚集诱导发射 (AIE) 活性，可确保在聚集状态下具有强发射。将QY-N用于雷公藤内酯源性肝损伤小鼠模型，实验结果表明QY-N可被肝脏NO激活，因此可用于检测中草药性肝损伤。三维 MSOT 图像提供的时空信息很好地描绘了肝损伤的部位和大小。此外，QY-N 还被用于监测治疗过程中肝损伤的康复情况。QY-NO 具有聚集诱导发射 (AIE) 活性，可确保在聚集状态下具有强发射。将QY-N用于雷公藤内酯源性肝损伤小鼠模型，实验结果表明QY-N可被肝脏NO激活，因此可用于检测中草药性肝损伤。三维 MSOT 图像提供的时空信息很好地描绘了肝损伤的部位和大小。此外，QY-N 还被用于监测治疗过程中肝损伤的康复情况。三维 MSOT 图像提供的时空信息很好地描绘了肝损伤的部位和大小。此外，QY-N 还被用于监测治疗过程中肝损伤的康复情况。三维 MSOT 图像提供的时空信息很好地描绘了肝损伤的部位和大小。此外，QY-N 还被用于监测治疗过程中肝损伤的康复情况。

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An Activatable Probe with Aggregation-Induced Emission for Detecting and Imaging Herbal Medicine Induced Liver Injury with Optoacoustic Imaging and NIR-II Fluorescence Imaging

Whilte herbal medicines are widely used for health promotion and therapy for chronic conditions, inappropriate use of them may cause adverse effects like liver injury, and accurately evaluating their hepatotoxicity is of great significance for public health. Herein, an activatable probe QY-N for diagnosing herbal-medicine-induced liver injury by detecting hepatic NO with NIR-II fluorescence and multispectral optoacoustic tomography (MSOT) imaging is demonstrated. The probe includes a bismethoxyphenyl-amine-containing dihydroxanthene serving as electron donor, a quinolinium as electron acceptor, and a butylamine as recognition group and fluorescence quencher. The hepatic level of NO reacts with butylamine, thereby generating the activated probe QY-NO which exhibits a red-shifted absorption band (700–850 nm) for optoacoustic imaging and generates strong emission (910–1110 nm) for NIR-II fluorescence imaging. QY-NO is aggregation-induced-emission (AIE) active, which ensures strong emission in aggregated state. QY-N is utilized in the triptolide-induced liver injury mouse model, and experimental results demonstrate the QY-N can be activated by hepatic NO and thus be used in detecting herbal-medicine-induced liver injury. The temporal and spatial information provided by three-dimensional MSOT images well delineates the site and size of liver injury. Moreover, QY-N has also been employed to monitor rehabilitation of liver injury during treatment process.

更新日期：2021-06-23

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