Tricaine (MS222) is a widely-used compound in fish anesthesia in aquaculture, transportation, and research laboratories, but its use has certain safety risks due to the lack of relevant laws and regulations. Herein, a simple and efficient one-step corrosion method was used to prepare a nanoporous gold (NPG) electrochemical sensor for detecting MS222. Under 0.1 M H₂SO₄ buffer solution, NPG showed a strong electrocatalytic redox effect on MS222, a wide linear range of 5 μg·mL⁻¹ ~ 100 μg·mL⁻¹, a low detection limit of as low as 0.29 μg·mL⁻¹, and good applicability in actual sample of the recovery rate as 94.89%~107.93%. Thus, this work demonstrates the basic advantages of NPG and provides good application potential for the rapid detection of fishery anesthetic MS222.

Tricaine（MS222）是水产养殖、运输和研究实验室广泛用于鱼类麻醉的化合物，但由于缺乏相关法律法规，其使用存在一定的安全风险。在此，采用一种简单高效的一步腐蚀方法制备了一种用于检测 MS222 的纳米多孔金 (NPG) 电化学传感器。在0.1 MH ₂ SO ₄缓冲液下，NPG对MS222表现出很强的电催化氧化还原作用，线性范围宽5 μg·mL ^-1  ~ 100 μg·mL ^-1，检测下限低至0.29 μg·mL ⁻¹，回收率94.89%~107.93%，在实际样品中具有良好的适用性。因此，这项工作展示了NPG的基本优势，并为渔业麻醉剂MS222的快速检测提供了良好的应用潜力。