Visible-Light-Induced Trifluoromethylation of Allylic Alcohols,Organic Letters

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Visible-Light-Induced Trifluoromethylation of Allylic Alcohols
Organic Letters ( IF 4.9 ) Pub Date : 2021-06-22 , DOI: 10.1021/acs.orglett.1c01767
Bowen Li ₁ , Wubing Zeng ₁ , Lin Wang ₁ , Zhishuai Geng ₂ , Teck-Peng Loh ₃ , Peizhong Xie ₁

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An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF₃SO₂Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO₂ was reutilized to activate C–OH bond, which enabled this dehydroxylative trifluoromethylation to be performed conveniently. A variety of multifunctionalized CF₃-allylic compounds were obtained in high yields and excellent stereoselectivity.

中文翻译：

烯丙醇的可见光诱导三氟甲基化

以环境友好的方式开发了有机光氧化还原催化的烯丙醇脱羟基三氟甲基化。本反应选用易得的CF ₃ SO ₂ Na作为三氟甲基化试剂。在原位通过产品生成SO ₂被再利用来激活C-OH键，这使此dehydroxylative三氟甲基化将被方便地进行。以高产率和优异的立体选择性获得了多种多功能化的 CF _{3 -}烯丙基化合物。

更新日期：2021-07-02

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