Inhibition of RhoA/Rho kinase signaling pathway by fasudil protects against kainic acid-induced neurite injury,Brain and Behavior

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Inhibition of RhoA/Rho kinase signaling pathway by fasudil protects against kainic acid-induced neurite injury
Brain and Behavior ( IF 2.6 ) Pub Date : 2021-06-22 , DOI: 10.1002/brb3.2266
Yingchun Xiang ₁ , Yumiao Niu _{1,

2} , Yacong Xie _{1,

2} , Shishuo Chen _{1,

2} , Feng Zhu ₂ , Weida Shen ₂ , Ling-Hui Zeng _{1,

2}

Affiliation

RhoA/Rho kinase pathway is essential for regulating cytoskeletal structure. Although its effect on normal neurite outgrowth has been demonstrated, the role of this pathway in seizure-induced neurite injury has not been revealed. The research examined the phosphorylation level of RhoA/Rho kinase signaling pathway and to clarify the effect of fasudil on RhoA/Rho kinase signaling pathway and neurite outgrowth in kainic acid (KA)-treated Neuro-2A cells and hippocampal neurons.

中文翻译：

法舒地尔抑制 RhoA/Rho 激酶信号通路可防止红藻氨酸诱导的神经突损伤

RhoA/Rho 激酶通路对于调节细胞骨架结构至关重要。尽管已证明其对正常神经突生长的影响，但尚未揭示该途径在癫痫引起的神经突损伤中的作用。该研究检查了 RhoA/Rho 激酶信号通路的磷酸化水平，并阐明了法舒地尔对红藻氨酸 (KA) 处理的 Neuro-2A 细胞和海马神经元中 RhoA/Rho 激酶信号通路和神经突生长的影响。

更新日期：2021-06-22

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