Dissolvable microneedle patches (MNPs) enable simplified delivery of therapeutics via the skin. However, most dissolvable MNPs do not deliver their full drug loading to the skin because only some of the drug is localized in the microneedles (MNs), and the rest remains adhered to the patch backing after removal from the skin. In this work, biphasic dissolvable MNPs are developed by mounting water-soluble MNs on a water-insoluble backing layer. These MNPs enable the drug to be contained in the MNs without migrating into the patch backing due to the inability of the drugs to partition into the hydrophobic backing materials during MNP fabrication. In addition, the insoluble backing is poorly wetted upon MN dissolution in the skin, which significantly reduces drug residue on the MNP backing surface after application. These effects enable a drug delivery efficiency of >90% from the MNPs into the skin 5 min after application. This study shows that the biphasic dissolvable MNPs can facilitate efficient drug delivery to the skin, which can improve the accuracy of drug dosing and reduce drug wastage.

中文翻译：

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使用具有水不溶性背衬的双相可溶性微针贴片将药物有效递送至皮肤

可溶性微针贴片 (MNP) 可简化通过皮肤递送治疗药物。然而，大多数可溶解的 MNP 不会将其全部药物负载输送到皮肤，因为只有一些药物位于微针 (MN) 中，其余药物在从皮肤去除后仍粘附在贴片背衬上。在这项工作中，通过将水溶性 MN 安装在水不溶性背衬层上来开发双相可溶性 MNP。由于在 MNP 制造过程中药物无法分配到疏水性背衬材料中，这些 MNP 使药物能够包含在 MN 中而不会迁移到贴片背衬中。此外，不溶性背衬在 MN 溶解在皮肤中时润湿性差，这显着减少了施用后 MNP 背衬表面上的药物残留。这些效应使 MNPs 在施用后 5 分钟内将药物输送到皮肤的效率达到 > 90%。本研究表明，双相可溶性 MNPs 可以促进药物有效输送到皮肤，从而提高药物给药的准确性并减少药物浪费。