用于化学发光免疫分析的溴化铯铅 (CsPbBr3) 钙钛矿量子点光电传感器,ACS Applied Materials & Interfaces

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用于化学发光免疫分析的溴化铯铅 (CsPbBr3) 钙钛矿量子点光电传感器
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-06-17 , DOI: 10.1021/acsami.1c08128
Hong-Rae Kim ₁ , Ji-Hong Bong ₁ , Jun-Hee Park ₁ , Zhiquan Song ₁ , Min-Jung Kang ₂ , Dong Hee Son ₃ , Jae-Chul Pyun ₁

Affiliation

化学发光免疫测定已广泛用于诊断各种疾病。然而，由于化学发光信号的强度极低，因此需要高灵敏度的换能器，例如光电倍增管和带有冷却装置的图像传感器来克服这一缺点。在这项研究中，开发了一种基于溴化铯铅 (CsPbBr ₃ ) 钙钛矿量子点 (QD) 的超灵敏光电传感器，其对化学发光免疫分析具有足够高的灵敏度。首先，在热力学控制下合成了具有高度均匀尺寸（即 5 nm）的CsPbBr ₃ QD，以实现高尺寸限制效果。用于制造光电传感器，MoS ₂纳米薄片用作电子传输层并在最佳温度下进行热处理。此外，聚对二甲苯-C 薄膜用作钝化层，以提高光传感器的物理稳定性和灵敏度。特别是，钝化层减少了 CsPbBr ₃ QD上的陷阱态，提高了灵敏度。最后，基于 CsPbBr ₃ QD的光电传感器用于化学发光免疫分析，用于检测人类乙型肝炎表面抗原、人类免疫缺陷病毒抗体和甲胎蛋白（AFP，一种癌症生物标志物）。与常规使用的设备相比，该光电传感器被确定可用于化学发光免疫分析。

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Cesium Lead Bromide (CsPbBr3) Perovskite Quantum Dot-Based Photosensor for Chemiluminescence Immunoassays

Chemiluminescence immunoassays have been widely employed for diagnosing various diseases. However, because of the extremely low intensity chemiluminescence signals, highly sensitive transducers, such as photomultiplier tubes and image sensors with cooling devices, are required to overcome this drawback. In this study, a hypersensitive photosensor was developed based on cesium lead bromide (CsPbBr₃) perovskite quantum dots (QDs) with sufficient high sensitivity for chemiluminescence immunoassays. First, CsPbBr₃ QDs with a highly uniform size, that is, 5 nm, were synthesized under thermodynamic control to achieve a high size confinement effect. For the fabrication of the photosensor, MoS₂ nanoflakes were used as an electron transfer layer and heat-treated at an optimum temperature. Additionally, a parylene-C film was used as a passivation layer to improve the physical stability and sensitivity of the photosensor. In particular, the trap states on the CsPbBr₃ QDs were reduced by the passivation layer, and the sensitivity was increased. Finally, a photosensor based on CsPbBr₃ QDs was employed in chemiluminescence immunoassays for the detection of human hepatitis B surface antigen, human immunodeficiency virus antibody, and alpha-fetoprotein (AFP, a cancer biomarker). When compared with the conventionally used equipment, the photosensor was determined to be feasible for application in chemiluminescence immunoassays.

更新日期：2021-06-30

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