Comprehensively understanding the albumin and fibrinogen adsorption behaviors is of fundamental significance for blood-contacting devices to effectively prevent the proteins adsorption. First, a controllable superhydrophobic surface presented great repellence to different liquids with water contact angle 165.2°, plasma contact angle 154.8° and blood contact angle 152.1°. Secondly, the albumin and fibrinogen adhesion tests indicated that the pure titanium surface was fully covered by the proteins layer while only a small amount of the proteins adhered to the superhydrophobic surface. Furthermore, the extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) model was built by considering the Lifshitz-van der Waals (LW), the Lewis acid-base (AB) and the electrostatic double-layer (EL) interactions, the positive value of total interaction energy profile suggested that an overall repulsive interaction between the protein molecules and superhydrophobic surface happened at a small separation distance. Finally, the hollow tubes with inner superhydrophobic surface were implanted into carotid artery of rabbits for two weeks. The content of N element measured by EDS mapping provide a new evidence that superhydrophobic surface owns a great resistance of the proteins absorption, and no thrombosis or blood cells adhered to the superhydrophobic surface. This research revealed the mechanism that superhydrophobic modification could effectively prevent the adsorption of plasma proteins, which could provide some theoretical basis to help design the blood-contacting devices with great hemocompatibility.

全面了解白蛋白和纤维蛋白原的吸附行为对于血液接触装置有效防止蛋白质吸附具有根本意义。首先，可控的超疏水表面对不同的液体表现出很强的排斥性，水接触角为 165.2°，血浆接触角为 154.8°，血液接触角为 152.1°。其次，白蛋白和纤维蛋白原粘附测试表明纯钛表面完全被蛋白质层覆盖，而只有少量蛋白质粘附在超疏水表面上。此外，扩展的 Derjaguin-Landau-Verwey-Overbeek (XDLVO) 模型是通过考虑 Lifshitz-van der Waals (LW)、Lewis 酸碱 (AB) 和静电双层 (EL) 相互作用建立的，总相互作用能谱的正值表明蛋白质分子和超疏水表面之间的整体排斥相互作用发生在很小的分离距离处。最后，将具有内部超疏水表面的空心管植入兔颈动脉两周。EDS图谱测得的N元素含量为超疏水表面对蛋白质的吸收具有很大的抵抗力，并且没有血栓形成或血细胞粘附在超疏水表面上提供了新的证据。该研究揭示了超疏水修饰有效阻止血浆蛋白吸附的机制，为设计具有良好血液相容性的血液接触装置提供了一定的理论依据。