Visible-light-induced iodine-anion-catalyzed decarboxylative/deaminative C–H alkylation of enamides,Organic Chemistry Frontiers

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Visible-light-induced iodine-anion-catalyzed decarboxylative/deaminative C–H alkylation of enamides
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2021-6-7 , DOI: 10.1039/d1qo00660f
Jia-Xin Wang _{1,

2,

3,

4,

5} , Ya-Ting Wang _{1,

2,

3,

4,

5} , Hao Zhang _{1,

2,

3,

4,

5} , Ming-Chen Fu _{1,

2,

3,

4,

5}

Affiliation

A visible-light-induced iodine-anion-catalyzed C–H stereoselective alkylation of enamides has been developed. Redox-active esters and Katritzky salts of amino acids were found to be amenable for decarboxylative/deaminative cross-coupling reactions, delivering various functionalized enamides with excellent functional group tolerance. The reaction proceeded via photoactivation of the transiently assembled chromophores, avoiding the use of exogenous precious photoredox catalysts.

中文翻译：

可见光诱导的碘阴离子催化的烯酰胺的脱羧/脱氨基C-H烷基化

已开发出可见光诱导的碘阴离子催化的烯酰胺的 C-H 立体选择性烷基化。发现氧化还原活性酯和氨基酸的卡特里茨基盐适用于脱羧/脱氨基交叉偶联反应，提供具有优异官能团耐受性的各种官能化烯酰胺。该反应通过瞬时组装的发色团的光活化进行，避免使用外源性珍贵的光氧化还原催化剂。

更新日期：2021-06-17

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