Intraoperative imaging device for glioblastoma multiforme surgery: Review of Raman-based intraoperative imaging and introduction of a novel handheld probe technology,Journal of Raman Spectroscopy

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Intraoperative imaging device for glioblastoma multiforme surgery: Review of Raman-based intraoperative imaging and introduction of a novel handheld probe technology
Journal of Raman Spectroscopy ( IF 2.4 ) Pub Date : 2021-06-15 , DOI: 10.1002/jrs.6101
Mandana Behbahani ₁ , Bijentimala Keisham ₂ , Clayton L. Rosinski ₁ , Vikas Berry ₂ , Ankit I. Mehta ₁

Affiliation

Glioblastoma multiforme (GBM) is a malignant primary brain tumor with poor prognosis. Degree of resection contributes greatly to improved prognosis. Review of the literature for intraoperative hand-held Raman probes technology to enhance maximal gross total resection was conducted. Additionally, we introduce study of Raman shift of graphene, as the biosensing interface with tumor, to enhance the current model of hand-held probes. Retrospective analysis of the literature was conducted using pubMed database to delineate various intraoperative hand-held probes with a particular focus on Raman spectroscopic (RS) technology in neuronal tissue. Summary of our group's recent publications in this area is included. Literature review demonstrates ability of Raman Spectroscopy (RS) to distinguish normal glial tissue from that of pathologic tissue (GBM) with great accuracy, sensitivity, and specificity. Furthermore, addition of nano sensors, such as gold particles, has proven successful in enhancing the detection of tumor and normal brain interface. Our work has previously demonstrated graphene as a feasible biosensor to be used in conjunction with RS in detecting GBM cells. Intra operative handheld Raman probes (RP) have advanced overtime as an additive tool to help surgeons clearly distinguish tumor and normal brain interface. Optimal biosensors can significantly enhance the detection of such margins, thereby, aiding in more precise gross total resection.

中文翻译：

用于多形性胶质母细胞瘤手术的术中成像设备：基于拉曼的术中成像回顾和新型手持探针技术的引入

多形性胶质母细胞瘤（GBM）是一种恶性原发性脑肿瘤，预后较差。切除程度大大有助于改善预后。回顾了术中手持拉曼探针技术以提高最大总切除量的文献。此外，我们介绍了石墨烯的拉曼位移研究，作为与肿瘤的生物传感界面，以增强手持探针的当前模型。使用 pubMed 数据库对文献进行回顾性分析，以描绘各种术中手持探头，特别关注神经元组织中的拉曼光谱 (RS) 技术。包括我们小组最近在该领域发表的论文摘要。文献综述证明了拉曼光谱 (RS) 能够以极高的准确性、灵敏度和特异性区分正常神经胶质组织和病理组织 (GBM)。此外，添加纳米传感器，如金颗粒，已被证明成功地增强了对肿瘤和正常大脑界面的检测。我们的工作先前已经证明石墨烯是一种可行的生物传感器，可与 RS 结合用于检测 GBM 细胞。术中手持拉曼探针 (RP) 作为一种附加工具，可以帮助外科医生清楚地区分肿瘤和正常大脑界面。最佳生物传感器可以显着增强对此类边缘的检测，从而有助于更精确的总切除术。例如金颗粒，已被证明成功地增强了对肿瘤和正常大脑界面的检测。我们的工作先前已经证明石墨烯是一种可行的生物传感器，可与 RS 结合用于检测 GBM 细胞。术中手持拉曼探针 (RP) 作为一种附加工具，可以帮助外科医生清楚地区分肿瘤和正常大脑界面。最佳生物传感器可以显着增强对此类边缘的检测，从而有助于更精确的总切除术。例如金颗粒，已被证明成功地增强了对肿瘤和正常大脑界面的检测。我们的工作先前已经证明石墨烯是一种可行的生物传感器，可与 RS 结合用于检测 GBM 细胞。术中手持拉曼探针 (RP) 作为一种附加工具，可以帮助外科医生清楚地区分肿瘤和正常大脑界面。最佳生物传感器可以显着增强对此类边缘的检测，从而有助于更精确的总切除术。术中手持拉曼探针 (RP) 作为一种附加工具，可以帮助外科医生清楚地区分肿瘤和正常大脑界面。最佳生物传感器可以显着增强对此类边缘的检测，从而有助于更精确的总切除术。术中手持拉曼探针 (RP) 作为一种附加工具，可以帮助外科医生清楚地区分肿瘤和正常大脑界面。最佳生物传感器可以显着增强对此类边缘的检测，从而有助于更精确的总切除术。

更新日期：2021-07-07

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