In this work, the reactivity of 5-bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one toward primary aliphatic amines was studied. The reaction was found to be extremely selective to synthesize a series of 1-alkyl-4-(aminoalkyl)-2-(trifluoromethyl)-1H-pyrroles (13 examples, up to 90% yield) and a series of highly functionalized β-enaminones (6 examples, up to 78% yield), with only the amount of amine and the reaction conditions needing to be controlled. The structure of the products was unambiguously determined by single crystal X-ray diffraction and 2D NMR experiments.

中文翻译：

---

高度官能化的 4-氨基-2-(三氟甲基)-1H-吡咯的合成

在这项工作中，研究了 5-bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one 对脂肪族伯胺的反应性。发现该反应对合成一系列 1-烷基-4-（氨基烷基）-2-（三氟甲基）-1H-吡咯（13 个实例，产率高达 90%）和一系列高度官能化的 β-烯胺酮（6个例子，产率高达78%），只需要控制胺的量和反应条件。通过单晶 X 射线衍射和 2D NMR 实验明确确定了产物的结构。