人类男性包皮的感觉神经支配：迈斯纳小体占主导地位,Journal of Anatomy

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人类男性包皮的感觉神经支配：迈斯纳小体占主导地位
Journal of Anatomy ( IF 1.8 ) Pub Date : 2021-06-12 , DOI: 10.1111/joa.13481
Yolanda García-Mesa ₁ , Jorge García-Piqueras ₁ , Ramón Cobo ₁ , José Martín-Cruces ₁ , Iván Suazo _{1,

2} , Olivia García-Suárez ₁ , Jorge Feito _{1,

3,

4} , José A Vega _{1,

2}

Affiliation

迈斯纳小体是男性包皮无毛皮肤中最丰富的感觉小体。它们是 I 型、快速适应、低阈值的机械感受器，其功能与机械蛋白压电型机械敏感离子通道组分 2 (PIEZO2) 的表达有关。生殖器迈斯纳小体的刺激会产生性感觉。最近已经证明，数字迈斯纳小体、迈斯纳样小体和生殖器末端球具有围绕其神经元元件的神经内膜样囊。也就是说，轴突和神经胶质层状细胞及其轴突显示 PIEZO2 免疫反应性。尚不清楚包皮的迈斯纳小体是否也是如此。此外，在 Meissner 中发现的某些蛋白质的表达尚未在包皮的迈斯纳小体中研究其他解剖位置的小体，尤其是在手指中的小体。在这里，我们使用免疫组织化学来研究轴突（神经丝、神经元特异性烯醇化酶）、神经胶质（S100 蛋白、神经胶质纤维酸性蛋白、波形蛋白）、神经内膜 (CD34) 和神经周围 (葡萄糖转运蛋白 1) 标记在包皮和年龄在 5 至 23 岁之间的男性参与者的数字迈斯纳小体。此外，我们调查了男性包皮迈斯纳小体中机械蛋白 PIEZO2 的发生情况。人类男性包皮中含有大量的迈斯纳小体，这些小体可能是成组的，也可能是孤立的，并且有规律地分布在真皮乳头中。层状胶质细胞表现出强烈的 S100 蛋白和波形蛋白表达，但缺乏胶质纤维酸性蛋白的表达。此外，它们表现出轴突 PIEZO2 表达并具有神经内膜囊，但没有神经周围膜。我们的研究结果表明，人类男性包皮迈斯纳小体共享数字迈斯纳小体的免疫组织化学特征，这被认为是机械转导所必需的。这些数据强烈表明迈斯纳小体的结构和功能与其解剖位置无关。这被认为是机械转导所必需的。这些数据强烈表明迈斯纳小体的结构和功能与其解剖位置无关。这被认为是机械转导所必需的。这些数据强烈表明迈斯纳小体的结构和功能与其解剖位置无关。

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Sensory innervation of the human male prepuce: Meissner's corpuscles predominate

Meissner's corpuscles are the most abundant sensory corpuscles in the glabrous skin of the male prepuce. They are type I, rapidly adapting, low-threshold mechanoreceptors, and their function is linked to the expression of the mechanoprotein piezo-type mechanosensitive ion channel component 2 (PIEZO2). Stimulation of genital Meissner's corpuscles gives rise to sexual sensations. It has been recently demonstrated that digital Meissner's corpuscles, Meissner-like corpuscles, and genital end bulbs have an endoneurium-like capsule surrounding their neuronal elements; that is, the axon and glial lamellar cells, and their axons, display PIEZO2 immunoreactivity. It is unknown whether this is also the case for preputial Meissner's corpuscles. Furthermore, the expression of certain proteins that have been found in Meissner's corpuscles at other anatomical locations, especially in the digits, has not been investigated in preputial Meissner's corpuscles. Here, we used immunohistochemistry to investigate the expression of axonal (neurofilament, neuron-specific enolase), glial (S100 protein, glial fibrillary acidic protein, vimentin), endoneurial (CD34), and perineurial (glucose transporter 1) markers in the preputial and digital Meissner's corpuscles of male participants aged between 5 and 23 years. Furthermore, we investigated the occurrence of the mechanoprotein PIEZO2 in male preputial Meissner's corpuscles. Human male prepuce contains numerous Meissner's corpuscles, which may be grouped or isolated and are regularly distributed in the dermal papillae. Lamellar glial cells display strong expression of S100 protein and vimentin but lack expression of glial fibrillary acidic protein. In addition, they show axonal PIEZO2 expression and have an endoneurial capsule, but no perineurial. Our results indicate that human male preputial Meissner's corpuscles share the immunohistochemical profile of digital Meissner's corpuscles, which is considered to be necessary for mechanotransduction. These data strongly suggest that the structure and function of Meissner's corpuscles are independent of their anatomical location.

更新日期：2021-06-12

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