Property Regulation of Conjugated Oligoelectrolytes with Polyisocyanide to Achieve Efficient Photodynamic Antibacterial Biomimetic Hydrogels,ACS Applied Materials & Interfaces

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Property Regulation of Conjugated Oligoelectrolytes with Polyisocyanide to Achieve Efficient Photodynamic Antibacterial Biomimetic Hydrogels
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-06-14 , DOI: 10.1021/acsami.1c06659
Changsheng Du ₁ , Dong Gao ₁ , Mengshi Gao ₁ , Hongbo Yuan ₁ , Xiaoning Liu ₁ , Bing Wang _{2,

3} , Chengfen Xing ₁

Affiliation

Fabricating antibacterial hydrogels with antimicrobial drugs and synthetic biocompatible biomimetic hydrogels is a promising strategy for practical medical applications. Here, we report a bicomponent hydrogel composed of a biomimetic polyisocyanopetide (PIC) hydrogel and a photodynamic antibacterial membrane-intercalating conjugated oligoelectrolyte (COE). The aggregation behavior and aggregate size of the COEs in water can be regulated using the PIC hydrogel, which could induce COEs with higher reactive oxygen species (ROS) production efficiency and increased association of COEs toward bacteria, therefore enhancing the antibacterial efficiency. This strategy provides a facile method for developing biomimetic hydrogels with high antibacterial capability.

中文翻译：

共轭低聚电解质与聚异氰化物的性能调节以实现高效的光动力抗菌仿生水凝胶

用抗菌药物和合成的生物相容性仿生水凝胶制造抗菌水凝胶是实际医学应用的一种有前途的策略。在这里，我们报告了一种由仿生聚异氰肽 (PIC) 水凝胶和光动力抗菌膜嵌入共轭低聚电解质 (COE) 组成的双组分水凝胶。COEs 在水中的聚集行为和聚集体大小可以使用 PIC 水凝胶进行调节，这可以诱导具有更高活性氧 (ROS) 生产效率的 COEs 和增加 COEs 与细菌的结合，从而提高抗菌效率。该策略为开发具有高抗菌能力的仿生水凝胶提供了一种简便的方法。

更新日期：2021-06-23

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