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Synthesis of benzo[f]pyrido[1,2-a]indole-6,11-diones via the I2-promoted reactions of methyl ketones with pyridines and 1,4-naphthoquinone
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2021-06-13 , DOI: 10.1016/j.tetlet.2021.153235
Yun Liu , Hui Xu , Hui Wu

An effective synthesis of benzo[f]pyrido[1,2-a]indole-6,11-diones has been achieved via the I2-promoted reactions of methyl ketones, pyridines and 1,4-naphthoquinone. In this reaction, either aromatic or aliphatic methyl ketones proceeded well. The advantages of this method include a broad substrate scope, metal-free reaction conditions, and high atom- and step-economy.



中文翻译:

通过甲基酮与吡啶和 1,4-萘醌的 I2 促进反应合成苯并[f]吡啶并[1,2-a]吲哚-6,11-二酮

苯并[ f ]吡啶并[1,2 - a ]吲哚-6,11-二酮的有效合成已通过甲基酮、吡啶和1,4-萘醌的I 2促进反应实现。在该反应中,芳香族或脂肪族甲基酮都进行得很好。该方法的优点包括底物范围广、反应条件无金属、原子经济和步骤经济性高。

更新日期:2021-07-24
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