We have discovered that trifluoroacetic acid is an efficient catalyst to accelerate the Petasis three-component, one-pot process, reducing reaction times, and offering good to excellent yields. A series of azaarene-derived glycines have been successfully achieved via the TFA-accelerated Petasis reaction. To our best knowledge, the use of TFA to accelerate Petasis reaction has not been reported in the literature. By virtue of the operational simplicity, the present TFA-catalyzed Petasis reaction, capable of shortening reaction times, might find applications in other instances of the widely used Petasis reaction.

中文翻译：

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三氟乙酸促进的矮小三组分反应：吲哚啉衍生的甘氨酸的合成

我们已经发现，三氟乙酸是一种有效的催化剂，可以加快Petasis三组分一锅法的生产，缩短反应时间，并提供良好至极好的收率。通过TFA加速的Petasis反应已成功实现了一系列氮杂芳烃衍生的甘氨酸。据我们所知，在文献中尚未报道使用TFA来促进Petasis反应。由于操作简单，本发明的TFA催化的Petasis反应能够缩短反应时间，可能在广泛使用的Petasis反应的其他情况下得到应用。