A novel two-dimensional Cd-based metal–organic framework (MOF), [Cd(pddb)H₂O]_n (Cd-MOF), has been hydrothermally synthesized using the V-shaped ligand 4,4′-(pyridine-2,6-diyl)-dibenzoic acid (H₂pddb) and structurally characterized. The framework exhibits fascinating one-dimensional in-plane channels functionalized with active pyridine-N sites. The as-synthesized Cd-MOF exhibits excellent water and chemical stability. Furthermore, a simple and nondestructive coordinated postsynthetic modification method has been applied to Cd-MOF to obtain a class of MOF hybrids functionalized by lanthanide ions. More interestingly, Eu³⁺@Cd-MOF can act as a dual-emissive ratiometric fluorescent probe for 2-(2-methoxyethoxy) acetic acid (MEAA), a metabolite of 2-(2-methoxyethoxy) ethanol, which could result in DNA damage and teratogenic and developmental toxicity. During the sensing process, the fluorescence sensor exhibits notable water tolerance, reusability, and a low detection limit (8.5 μg mL^–1). In addition, the chemical substances in human urine and serum do not interfere with the fluorescence quenching process, which makes it possible for the fluorescent probe to be applied in the detection of MEAA in human urine and serum systems. The possible sensing mechanism is also studied and discussed in detail.

中文翻译：

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稳定的 Cd(II) 基金属-有机骨架：合成、结构及其 Eu ³⁺官能化，用于生物标志物 2-(2-Methoxyethoxy) 乙酸的比率传感

使用 V 型配体 4,4'-(吡啶-) 水热合成了一种新型二维 Cd 基金属有机骨架 (MOF) [Cd(pddb)H ₂ O] _n ( Cd-MOF ) 2,6-二基)-二苯甲酸 (H ₂ pddb) 和结构表征。该框架展示了具有活性吡啶-N 位点功能化的迷人一维面内通道。合成的Cd-MOF表现出优异的水和化学稳定性。此外，一种简单且无损的协调后合成修饰方法已应用于Cd-MOF，以获得一类由镧系元素离子功能化的 MOF 杂化物。更有趣的是，Eu ³⁺ @ Cd-MOF可作为 2-(2-甲氧基乙氧基) 乙酸 (MEAA) 的双发射比率荧光探针，它是 2-(2-甲氧基乙氧基) 乙醇的代谢物，可导致 DNA 损伤和致畸和发育毒性。在传感过程中，荧光传感器表现出显着的耐水性、可重复使用性和低检测限（8.5 μg mL ^–1）。此外，人尿和血清中的化学物质不会干扰荧光猝灭过程，这使得荧光探针可用于检测人尿和血清系统中的MEAA。还详细研究和讨论了可能的传感机制。