Au/Pt-Egg-in-Nest Nanomotor for Glucose-Powered Catalytic Motion and Enhanced Molecular Transport to Living Cells,Angewandte Chemie International Edition

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Au/Pt-Egg-in-Nest Nanomotor for Glucose-Powered Catalytic Motion and Enhanced Molecular Transport to Living Cells
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-06-09 , DOI: 10.1002/anie.202103827
Taewan Kwon _{1,

2} , Nitee Kumari _{1,

2} , Amit Kumar _{1,

2} , Jongwon Lim _{1,

2} , Chang Yun Son ₂ , In Su Lee _{1,

2,

3}

Affiliation

Nanostructures converting chemical energy to mechanical work by using benign metabolic fuels, have huge implications in biomedical science. Here, we introduce Au/Pt-based Janus nanostructures, resembling to “egg-in-nest” morphology (Au/Pt-ENs), showing enhanced motion as a result of dual enzyme-relay-like catalytic cascade in physiological biomedia, and in turn showing molecular-laden transport to living cells. We developed dynamic-casting approach using silica yolk-shell nanoreactors: first, to install a large Au-seed fixing the silica-yolk aside while providing the anisotropically confined concave hollow nanospace to grow curved Pt-dendritic networks. Owing to the intimately interfaced Au and Pt catalytic sites integrated in a unique anisotropic nest-like morphology, Au/Pt-ENs exhibited high diffusion rates and displacements as the result of glucose-converted oxygen concentration gradient. High diffusiophoresis in cell culture media increased the nanomotor-membrane interaction events, in turn facilitated the cell internalization. In addition, the porous network of Au/Pt-ENs facilitated the drug-molecule cargo loading and delivery to the living cells.

中文翻译：

Au/Pt-Egg-in-Nest Nanomotor 用于葡萄糖驱动的催化运动和增强的活细胞分子运输

纳米结构通过使用良性代谢燃料将化学能转化为机械功，在生物医学科学中具有巨大的意义。在这里，我们介绍了基于 Au/Pt 的 Janus 纳米结构，类似于“巢中蛋”形态（Au/Pt-EN s），由于生理生物介质中的双酶继电器样催化级联反应而显示出增强的运动，并反过来显示向活细胞的分子负载运输。我们开发了使用二氧化硅蛋黄壳纳米反应器的动态铸造方法：首先，安装一个大的 Au 种子，将二氧化硅蛋黄固定在一边，同时提供各向异性限制的凹空心纳米空间来生长弯曲的 Pt 树枝状网络。由于在独特的各向异性巢状形态中集成了紧密结合的 Au 和 Pt 催化位点，Au/Pt-EN由于葡萄糖转化的氧浓度梯度，s 表现出高扩散率和位移。细胞培养基中的高扩散电泳增加了纳米马达-膜相互作用事件，进而促进了细胞内化。此外，Au/Pt-EN的多孔网络促进了药物分子货物的装载和输送到活细胞。

更新日期：2021-07-27

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