Disodium (+)-(Z)-[[[1-{2-amino-4-[2-14C]thiazolyl)-2-[[ (2S,3S)-2-(carbamoyloxymethyl)-4-oxo-1-sulfonato-3-azetizinyl]amino-2-oxoethylidene]amino]oxy]acetate ([14C]AMA-1080) was synthesized via [2-(2-chloroacetamido-4-[2-14C]thiazoiyl)-(Z)-2-(4-nltrobenzyloxycarbonylmethoxyimino)]acetic acid from [14C]thiourea. Trisodium (+)-(Z)-[[[1-(2-amino-4-[2-14C]thiazoiyl)-2-[[(1S, 2S)-3-carbamoyloxy-1-carboxylato-2-sulfonato-aminopropyl]amino]-2-oxoethylidene]amino]oxy]acetate ([ 14C]AMA -1294) as the principal metabolite of [14C]AMA-1080 was also prepared.

中文翻译：

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(+)-(Z)-[[[[1-(2-amino-4-[2-14c]thiazolyl)2-[[(2s,3s)-2-(carbamoyloxymethyl)-4-oxo-]二钠的合成1-磺基-3-氮杂环丁烷基]氨基]-2-氧亚乙基]氨基]氧基]乙酸酯

二钠 (+)-(Z)-[[[1-{2-amino-4-[2-14C]thiazolyl)-2-[[ (2S,3S)-2-(carbamoyloxymethyl)-4-oxo-1 -sulfonato-3-azetizinyl]amino-2-oxoethylidene]amino]oxy]acetate ([14C]AMA-1080) 通过 [2-(2-chloroacetamido-4-[2-14C]thiazoiyl)-(Z) 合成来自[14C]硫脲的-2-(4-硝基苄氧基羰基甲氧基亚氨基)]乙酸。(+)-(Z)-[[[1-(2-amino-4-[2-14C]thiazoiyl)-2-[[(1S, 2S)-3-carbamoyloxy-1-carboxylato-2-sulfonato还制备了-氨基丙基]氨基]-2-氧代亚乙基]氨基]氧基]乙酸盐([ 14C] AMA -1294)作为[ 14 C] AMA-1080的主要代谢物。