Abstract A novel synthesis of 2-amino-5-methanesulfonylaminobenzenesulfonamide is described. This preparation begins with readily available 4-nitroaniline and proceeds through five steps (isolations) in 41% overall yield. The described chemistry is conducted on a 50- to 100-g scale and does not require extractive workup procedures or chromatographic purifications.

中文翻译：

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2-氨基-5-甲磺酰氨基苯磺酰胺的高效大规模合成

摘要 描述了 2-amino-5-methanesulfonylaminobenzosulfonamide 的新合成方法。该制备从容易获得的 4-硝基苯胺开始，并通过五个步骤（分离）进行，总产率为 41%。所描述的化学反应以 50 到 100 克的规模进行，不需要萃取后处理程序或色谱纯化。