Abstract A convenient synthetic route for the preparation of α-aminophosphonate derivatives of triethoxysilane, attractive precursors for silica surface functionalization, was developed. The condensation of commercially available APTES with carbonyl compounds followed by Pudovik reaction of imines with diethyl phosphite yielded desired N-phosphonomethyl functionalized (3-aminopropyl)triethoxysilanes in high yields without further purification. The chemical structures of obtained products were undoubtedly proved by 1H, 13C and 31P NMR spectroscopy, elemental analysis and mass spectrometry. Graphical Abstract

中文翻译：

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用于合成表面改性二氧化硅的三乙氧基硅烷的 α-氨基膦酸酯衍生物

摘要 开发了一种方便的合成路线，用于制备三乙氧基硅烷的 α-氨基膦酸酯衍生物，这是一种有吸引力的二氧化硅表面功能化前体。市售 APTES 与羰基化合物缩合，然后亚胺与亚磷酸二乙酯的 Pudovik 反应以高产率得到所需的 N-膦酰基甲基官能化（3-氨基丙基）三乙氧基硅烷，无需进一步纯化。所得产物的化学结构无疑通过 1H、13C 和 31P 核磁共振谱、元素分析和质谱证实。图形概要