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Synthesis of spirooxindole analogues from 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde
Synthetic Communications ( IF 1.8 ) Pub Date : 2019-12-27 , DOI: 10.1080/00397911.2019.1704009
Venkata Nookaapparao Gorli 1 , Rajagopal Srinivasan 1
Affiliation  

Abstract A series of spirooxindoles have been synthesized through 1,3-dipolar cycloaddition of an azomethine ylide generated from isatin and sarcosine or L-proline with the dipolarophile (E)-3-(2-cyclopropyl-5-(4-fluorophenyl) quinolin-3-yl)-1-phenylprop-2-en-1-one derivatives. The stereochemistry of the cycloadducts was assigned based on the single-crystal X-ray. GRAPHICAL ABSTRACT

中文翻译:

2-环丙基-4-(4-氟苯基)喹啉-3-甲醛合成螺羟吲哚类似物

摘要 通过由靛红和肌氨酸或 L-脯氨酸产生的偶氮甲碱叶立德与亲偶极试剂 (E)-3-(2-环丙基-5-(4-氟苯基) 喹啉的 1,3-偶极环加成反应合成了一系列螺吲哚。 -3-yl)-1-phenylprop-2-en-1-one 衍生物。环加合物的立体化学是根据单晶 X 射线确定的。图形概要
更新日期:2019-12-27
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