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Microwave-assisted three component synthesis of novel bis-fused quinazolin-8(4H)-ones linked to aliphatic or aromatic spacer via amide linkages
Synthetic Communications ( IF 1.8 ) Pub Date : 2020-02-14 , DOI: 10.1080/00397911.2020.1725575 Ibrahim M. Z. Fares 1 , Ahmed E. M. Mekky 1 , Ahmed H. M. Elwahy 1 , Ismail A. Abdelhamid 1
Synthetic Communications ( IF 1.8 ) Pub Date : 2020-02-14 , DOI: 10.1080/00397911.2020.1725575 Ibrahim M. Z. Fares 1 , Ahmed E. M. Mekky 1 , Ahmed H. M. Elwahy 1 , Ismail A. Abdelhamid 1
Affiliation
Abstract A novel series of bis(tetrahydro[1,2,4]triazolo[5,1-b]quinazolin-8-ones) and bis(tetrahydrobenzo[4,5]imidazo[2,1-b]quinazolinones) containing amide linkages were regionselectively prepared via a three-component reaction of bis(aldehydes) with dimedone and 3-amino-1,2,4-triazole (or 2-aminobenzimidazole) under conventional heating as well as under microwave irradiation. Graphical Abstract
中文翻译:
微波辅助三组分合成通过酰胺键连接到脂肪族或芳香族间隔基的新型双稠合喹唑啉-8(4H)-酮
摘要 含有酰胺的双(四氢[1,2,4]三唑并[5,1-b]喹唑啉-8-酮)和双(四氢苯并[4,5]咪唑并[2,1-b]喹唑啉酮)新系列在常规加热和微波辐射下,通过双(醛)与二甲酮和 3-氨基-1,2,4-三唑(或 2-氨基苯并咪唑)的三组分反应区域选择性地制备连接。图形概要
更新日期:2020-02-14
中文翻译:
微波辅助三组分合成通过酰胺键连接到脂肪族或芳香族间隔基的新型双稠合喹唑啉-8(4H)-酮
摘要 含有酰胺的双(四氢[1,2,4]三唑并[5,1-b]喹唑啉-8-酮)和双(四氢苯并[4,5]咪唑并[2,1-b]喹唑啉酮)新系列在常规加热和微波辐射下,通过双(醛)与二甲酮和 3-氨基-1,2,4-三唑(或 2-氨基苯并咪唑)的三组分反应区域选择性地制备连接。图形概要