ABSTRACT A novel preparation method of 2-(azidomethyl)benzoic acid, a precursor of (2-azidomethyl)benzoyl (AZMB) protective group, was developed which can provide pure sample in gram scale without chromatographic purifications. Reductive cleavage using triphenylphosphine was found to be effective in the case of sterically hindered ester that resists under basic hydrolysis.

中文翻译：

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(2-叠氮甲基)苯甲酸的新制备及其作为保护基团的应用

摘要 开发了一种制备（2-叠氮甲基）苯甲酰基（AZMB）保护基的前体 2-（叠氮甲基）苯甲酸的新方法，该方法无需色谱纯化即可提供克级纯样品。发现使用三苯基膦的还原裂解在抗碱性水解的位阻酯的情况下是有效的。