Abstract Lansoprazole (Prevacid) is an antiulcerative drug used for the treatment of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome. During the bulk synthesis of lansoprazole, we have observed five impurities: lansoprazole N-oxide, lansoprazole sulfone N-oxide, lansoprazole sulfide, lansoprazole sulfone and N-aralkyl lansoprazole. The present work describes the synthesis and characterization of these impurities.

中文翻译：

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兰索拉唑（一种抗溃疡药）的代谢物和潜在杂质的合成和表征

摘要 兰索拉唑 (Prevacid) 是一种抗溃疡药，用于治疗十二指肠和胃溃疡、反流性食管炎和 Zollinger-Ellison 综合征。在兰索拉唑的批量合成过程中，我们观察到五种杂质：兰索拉唑N-氧化物、兰索拉唑砜N-氧化物、兰索拉唑硫化物、兰索拉唑砜和N-芳烷基兰索拉唑。目前的工作描述了这些杂质的合成和表征。