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A Novel Route to Acyl Ureas: Syntheses of N-[5-(2-Chlorophenyl)-2-Furoyl]-N'-Arylthioureas and Ureas
Synthetic Communications ( IF 1.8 ) Pub Date : 2000-07-01 , DOI: 10.1080/00397910008087430
Zheng Li , Xicun Wang , Yuxia Da , Jichou Chen

Abstract A novel route to acyl ureas is described. Reaction of 5-(2-chlorophenyl)-2-furoyl chloride with ammonium thiocyanate first, then arylamine under phase transfer catalysis gives N-[5-(2-chlorophenyl)-2-furoyl]-N'-arylthioureas (1a-o). Compounds 1a-o on oxidation with potassium iodate respectively under reflux result in the formation of N-[5-(2-chlorophenyl)-2-furoyl]-N'-arylureas (2a-o).

中文翻译:

酰基脲的新途径:N-[5-(2-氯苯基)-2-呋喃酰基]-N'-芳基硫脲和脲的合成

摘要 描述了酰基脲的新途径。5-(2-氯苯基)-2-呋喃酰氯先与硫氰酸铵反应,然后芳胺在相转移催化下反应得到N-[5-(2-氯苯基)-2-呋喃酰]-N'-芳基硫脲(1a-o )。分别在回流下用碘酸钾氧化化合物 1a-o 导致形成 N-[5-(2-氯苯基)-2-呋喃酰基]-N'-芳基脲 (2a-o)。
更新日期:2000-07-01
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