A dual-response fluoran-phenothiazine hybrid fluorescent probe for selective sensing of Fe3+ and ClO− and cell imaging application,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

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A dual-response fluoran-phenothiazine hybrid fluorescent probe for selective sensing of Fe3+ and ClO− and cell imaging application
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ( IF 4.3 ) Pub Date : 2021-06-09 , DOI: 10.1016/j.saa.2021.120061
Qinghui Wang ₁ , Dasheng Zheng ₂ , Qiuhui Cao ₁ , Kun Huang ₁ , Dabin Qin ₁

Affiliation

Bifunctional fluorescent probes with dual-emission response attract extensive attention. A novel fluorescent probe FP, a hybrid of fluoran and phenothiazine, has been designed and synthesized for selective sensing of Fe³⁺ and ClO⁻ with dual-emission changes, which involes mechanisms of Fe³⁺-promoted spirolactone ring opening and ClO⁻-induced oxidation of phenothiazine moiety, respectively. In addition, the detection limits for Fe³⁺ and ClO⁻ were estimated to be 49.1 and 35.9 nM, respectively. Significantly, FP can be employed as an tracer for the detection of Fe³⁺ ions within living HeLa cells by fluorescence imaging.

中文翻译：

用于选择性感应 Fe ³⁺和 ClO ^-和细胞成像应用的双响应荧烷-吩噻嗪混合荧光探针

具有双发射响应的双功能荧光探针受到广泛关注。设计并合成了一种新型荧光探针FP，它是荧烷和吩噻嗪的混合物，用于选择性感应 Fe ³⁺和 ClO ^-具有双发射变化，这涉及 Fe ³⁺促进螺内酯开环和 ClO ^- - 的机制分别诱导吩噻嗪部分的氧化。此外，估计Fe ³⁺和 ClO ^-的检测限分别为 49.1 和 35.9 nM。值得注意的是，FP可用作检测 Fe ³⁺的示踪剂活的 HeLa 细胞内的离子通过荧光成像。

更新日期：2021-06-17

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