Immunology Although several mouse models of inflammatory bowel disease exist, Crohn's disease has been particularly difficult to model. Caruso et al. report a mouse model that recapitulates multiple hallmarks of intestinal inflammation seen in patients with Crohn's disease. Mice lacking two proteins, NOD2 and CYBB, develop spontaneous colitis that is driven by a Gram-negative gut bacterium, Mucispirillum schaedleri . Mice deficient in both NOD2 and CYBB developed colitis only after weaning because maternal antibodies protected them before weaning. In addition to developing a model for studying Crohn's disease, the study also highlights the importance of maternal antibodies in regulating immune homeostasis in early life. Sci. Immunol. 4 , eaaw4341 (2019).

中文翻译：

---

克罗恩病小鼠模型

免疫学 尽管存在多种炎症性肠病小鼠模型，但克罗恩病特别难以建模。卡鲁索等人。报告了一种小鼠模型，该模型概括了克罗恩病患者肠道炎症的多个标志。缺乏两种蛋白质 NOD2 和 CYBB 的小鼠会发展为由革兰氏阴性肠道细菌 Mucispirillum schaedleri 驱动的自发性结肠炎。缺乏 NOD2 和 CYBB 的小鼠仅在断奶后才发生结肠炎，因为母体抗体在断奶前保护了它们。除了开发用于研究克罗恩病的模型外，该研究还强调了母体抗体在调节生命早期免疫稳态方面的重要性。科学。免疫学。4、eaaw4341（2019）。