Near-Infrared Photothermal/Photodynamic-in-One Agents Integrated with a Guanidinium-Based Covalent Organic Framework for Intelligent Targeted Imaging-Guided Precision Chemo/PTT/PDT Sterilization,ACS Applied Materials & Interfaces

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Near-Infrared Photothermal/Photodynamic-in-One Agents Integrated with a Guanidinium-Based Covalent Organic Framework for Intelligent Targeted Imaging-Guided Precision Chemo/PTT/PDT Sterilization
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-06-08 , DOI: 10.1021/acsami.1c05705
Yu-Shi Liu ₁ , Xiang Wei ₁ , Xu Zhao _{1,

2,

3} , Li-Jian Chen _{1,

2,

3} , Xiu-Ping Yan _{1,

2,

3,

4}

Affiliation

Phototherapy holds great promise in the treatment of bacterial infections, especially the multidrug resistant bacterial infections. However, most therapeutic agents are based on the integration of individual photothermal agents and photosensitizers, always in the activated state, and generally lack bacterial specificity, resulting in uncertain pharmacokinetics and serious nonspecific damage to normal tissues. Herein, we report a pH-responsive nanoplatform with synergistic chemo-phototherapy function for smart fluorescence imaging-guided precision sterilization. pH reversible activated symmetric cyanine was designed and prepared as a bacterial-specific imaging unit and PTT/PDT-in-one agent. Meanwhile, a guanidinium-based covalent organic framework (COF) was employed as a nanocarrier and chemotherapy agent to build the intelligent nanoplatform via electrostatic self-assembly. The self-assembly of the PTT/PDT-in-one agent and the COF greatly improves the stability and blood circulation of the PTT/PDT-in-one agent and provides charge-reversed intelligent targeting ability. The developed smart nanoplatform not only enables bacterial-targeted imaging but also possesses chemo/PTT/PDT synergetic high-efficiency bactericidal effects with little side effects, showing great potential in practical applications.

中文翻译：

近红外光热/光动力一体化试剂与胍基共价有机框架相结合，用于智能靶向成像引导精准化疗/PTT/PDT灭菌

光疗法在治疗细菌感染，特别是多重耐药细菌感染方面具有广阔的前景。然而，大多数治疗剂都是基于单个光热剂和光敏剂的整合，始终处于激活状态，并且通常缺乏细菌特异性，导致药代动力学不确定，并对正常组织造成严重的非特异性损伤。在此，我们报告了一种具有协同化学光疗功能的 pH 响应纳米平台，用于智能荧光成像引导的精准灭菌。 pH 可逆活化对称花青被设计和制备为细菌特异性成像装置和 PTT/PDT 一体化试剂。同时，采用胍基共价有机框架（COF）作为纳米载体和化疗剂，通过静电自组装构建智能纳米平台。 PTT/PDT二合一制剂与COF的自组装大大提高了PTT/PDT二合一制剂的稳定性和血液循环，并提供电荷反转智能靶向能力。所开发的智能纳米平台不仅能够实现细菌靶向成像，而且具有化疗/PTT/PDT协同高效杀菌作用，且副作用小，在实际应用中显示出巨大的潜力。

更新日期：2021-06-23

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